Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approachShort communication Published on 2022-12-012022-10-05 Journal: Biochemistry and Biophysics Reports [Category] 신약개발, [키워드] annotations applied approach bioinformatics biological process CCR5 CD44 cellular component contribute CXCR4 demonstrated deregulation disease disease-associated drug Drug discovery Drug repurposing drug target evaluated Evidence facilitate functional functional annotation Genes genomic genomic variant genomic variants GWAS HLA-B identify implementation in-silico indication involved KEGG Missense mutation molecular overlapped Pathogenesis Pathway analysis provided risk SELP suggested target Treatment Tuberculosis variant [DOI] 10.1016/j.bbrep.2022.101334 [Article Type] Short communication
PTP1B inhibitors protect against acute lung injury and regulate CXCR4 signaling in neutrophilsArticle Published on 2022-07-222022-11-15 Journal: JCI Insight [Category] 진단, [키워드] Activation acute lung injury acute respiratory distress administration ameliorated antibody ARDS cause Cell Biology Chemokine receptor collateral tissue damage COVID-19 CXCR4 death dysregulated Effects etiologies highlight homeostasis implicated increased survival Inflammation inhibitor Lung injury mice Migration myeloperoxidase NET neutrophil Neutrophil extracellular trap neutrophil function neutrophils. phenotype Prevent prevented PROTECT Protein reduced regulate Sepsis Signaling signaling pathway survival syndrome Treatment tyrosine phosphatase [DOI] 10.1172/jci.insight.158199 PMC 바로가기
Hyperinflammatory environment drives dysfunctional myeloid cell effector response to bacterial challenge in COVID-19Research Article Published on 2022-01-102022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] abrogated Anti-inflammatory therapy anti-inflammatory treatment autocrine Bacterial Bacterial infection bacterial superinfection bacterial superinfections caused CD11b CD163 CD66b CD86 Cell cellular characterized classical Clusters complicate Course COVID-19 COVID-19 patient COVID-19 patients Critically ill CRP CXCR1 CXCR2 CXCR4 cytokine cytokine levels cytokine signaling Dexamethasone disease severity driven by dysregulated dysregulation elevated Ex vivo exacerbate exhibited expression function functional HLA-DR host response host-response hypercytokinemia Hyperinflammatory ICU IFN-γ IL-4 IL-6 level Immune cell immune cells immune response IMPROVE increased mortality induce Inflammatory marker inflammatory mediator Inflammatory mediators innate immune function Innate immunity low expression monocyte Monocytes MPO myeloid cell NET neutrophil paracrine paralysis patients phenotype phenotypic plasma provide receiving reduced reduction reduction in reflected response ROS production SARS-CoV-2 SARS-CoV-2 pathogenesis subsequent suppressed surface receptor Symptom synergistic systemic inflammation the disease TNF-α treated utility [DOI] 10.1371/journal.ppat.1010176 PMC 바로가기 [Article Type] Research Article
Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients With Different SeveritiesImmunology Published on 2022-01-032022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accompanied addition Analysis Antigen antigen processing B-cell CD14 CD69 CD83 collected Coronavirus disease 2019 COVID-19 CXCR4 dataset datasets dendritic cell dendritic cells disease severity downregulated downregulation exhibited FOS healthy controls HLA HLA class II HLA-DRA HLA-DRB1 IGHV3-21 immune Immune cell immune characteristics immune disorder Immunoglobulin JUN leukocyte memory T memory T cells monocyte mononuclear cell myeloid myeloid cells pathway Patient PBMCs performed Peripheral blood peripheral immune response plasmacytoid dendritic cell progression stage proportion recovered recovered COVID-19 patient Recovered COVID-19 patients recovered patient recovered patients Regulation reported severe symptom single-cell Single-cell RNA sequencing symptom onset T-cell differentiation upregulated upregulation [DOI] 10.3389/fimmu.2021.781432 PMC 바로가기 [Article Type] Immunology
Identification of Differentially Expressed Genes in COVID-19 and Integrated Bioinformatics Analysis of Signaling PathwaysCOVID-19에서 차별적으로 발현되는 유전자의 식별 및 신호 전달 경로의 통합 생물정보학 분석Research Article Published on 2021-12-242022-09-10 Journal: Genetics Research [Category] MERS, SARS, 유전자 메커니즘, [키워드] Analysis analyzed annotation bioinformatics cause CD69 cellular response chromosome complications coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cutoff CXCR4 cytokine cytokine production DAVID DEGs Diabetic diabetic complications Diagnosis Differentially expressed genes downregulated enrichment FN1 FoxO FOXP3 gene expression profile Gene ontology GO terms group GSEA help HLA-G hub genes identification IL-17 immune response involved ISG15 KEGG Kyoto leukocyte lung tissue mechanism MMP9 myeloid leukocyte necrotic necrotic cell death nuclear other disease pathway Pathways Pneumonia positive potential mechanisms potential molecular PPI protein-protein interaction RAGE Regulation Research screened selected signaling pathway target Treatment type I interferon upregulated Visualization [DOI] 10.1155/2021/2728757 PMC 바로가기 [Article Type] Research Article
COVID-19 Specific Immune Markers Revealed by Single Cell Phenotypic ProfilingArticle Published on 2021-11-292022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] acute respiratory syndrome Affect alteration caused Cell cell receptors characterized clinical outcomes complex coronavirus correlated COVID-19 COVID-19 patients CXCR4 defined Diagnosis Disease progression Effect exhibited expressed expression flow cytometry healthy blood donor heterogeneity highlight IFNGR1 immune Immune cell immune cells immune functions immune response increase in infected with SARS-CoV-2 inflammatory process less mononuclear cell patients with COVID-19 PBMCs performed Peripheral blood Profiling respiratory tract Revealed SARS-CoV-2 signaling pathway Single-cell RNA sequencing Specific subjects subset surface marker surface markers transcript viral infection was reduced [DOI] 10.3390/biomedicines9121794 PMC 바로가기 [Article Type] Article
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19420 Published on 2021-10-052022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, MERS, SARS, [키워드] Activation acute respiratory syndrome alteration basophils CD63 CD69 circulating clinical complication clinical feature Clinical features Clinical outcome collected combined use computational modeling convalescent convalescent phase coronavirus correlated COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patient COVID-19 patients COVID-19 severity CXCR4 detrimental dysregulated dysregulation eosinophil eosinophil and basophil activation Evidence expression flow cytometry granulocyte Granulocytic heterogeneity high-dimensional flow cytometry Hospitalization identify immature immune immune response immunotype indicate inflammatory markers inflammatory state innate immune response involved laboratory measurement longitudinal analysis Migration Multiorgan dysfunction neutrophil neutrophil heterogeneity Neutrophils pathophysiologic Patient Peripheral blood phenotypic phenotypic data predict predicted Predictive profiles Protein provide receptor Respiratory function reveal SARS-COV-2 infection selected severity of COVID-19 Significance significantly subset the disease viral immune responses virus clearance with COVID-19 [DOI] 10.1073/pnas.2109123118 PMC 바로가기 [Article Type] 420
Construction of an autophagy interaction network based on competitive endogenous RNA reveals the key pathways and central genes of SARS-CoV-2 infection in vivo경쟁적 내인성 RNA를 기반으로 한 자가포식 상호작용 네트워크의 구축은 생체 내 SARS-CoV-2 감염의 주요 경로 및 중심 유전자를 밝힙니다Article Published on 2021-09-012022-09-11 Journal: Microbial pathogenesis [Category] SARS, 유전자 메커니즘, [키워드] accompanied addition analyses Analysis autophagy bioinformatics biological processe biological processes Biomarker Biomarkers CCR2 central gene changes in construction Coronavirus infection COVID-19 CXCR4 cytokine receptor Cytokine storm datasets died differentially expressed differentially expressed miRNA differentially expressed miRNAs enriched pathway expression profile Gene Expression Omnibus GEO in vivo Infection Interaction investigated involved knowledge mechanism Messenger RNA microRNA MicroRNAs mild SARS-CoV-2 infection miRNA miRNAs miRNAs. MOST mRNA mRNAs Mutation pandemic Pathogenesis pathogenesis of SARS-CoV-2 pathway Pathway analysis patients with SARS-CoV-2 predict provided raw data receptor reveal RNA SARS-CoV-2 SARS-COV-2 infection severe symptom severe symptoms target the cytokine storm TP53INP2 variety virus strain virus strains [DOI] 10.1016/j.micpath.2021.105051 PMC 바로가기 [Article Type] Article
Emerging Importance of Chemokine Receptor CXCR4 and Its Ligand in Liver DiseaseReview Published on 2021-07-272023-08-30 Journal: Frontiers in Cell and Developmental Biology [Category] E형 간염, [키워드] CXCL12 CXCR4 Liver disease liver specific cells stem cells targeted therapy [DOI] 10.3389/fcell.2021.716842 PMC 바로가기 [Article Type] Review
Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19Research article Published on 2021-06-292022-10-05 Journal: Cell Reports [Category] 유전자 메커니즘, [키워드] activated acute respiratory syndrome bystander CD127 contribute coronavirus COVID-19 Critical CXCR4 death distinctive feature Effect elevated Escalation fatal COVID-19 homeostatic Immunity immunopathology individual individuals with COVID-19 Inflammatory limit lung Mild Pathogenesis phenotypic feature predict proliferation promote proportion Regulatory T cell relative robust SARS-CoV-2 SARS-CoV-2-specific T cell severe coronavirus disease severe COVID-19 severity Support T cell T cell response T cells [DOI] 10.1016/j.celrep.2021.109414 [Article Type] Research article